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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
2004 1
2005 2
2006 2
2007 2
2008 1
2010 2
2011 5
2012 2
2013 4
2014 3
2015 2
2016 2
2017 2
2018 2
2019 5
2020 6
2021 5
2022 6
2023 6
2024 3

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60 results

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Page 1
RAS Proteins and Their Regulators in Human Disease.
Simanshu DK, Nissley DV, McCormick F. Simanshu DK, et al. Cell. 2017 Jun 29;170(1):17-33. doi: 10.1016/j.cell.2017.06.009. Cell. 2017. PMID: 28666118 Free PMC article. Review.
Atypical KRASG12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D, Campbell SL, Petricoin EF 3rd, Simanshu DK, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ. Hobbs GA, et al. Among authors: simanshu dk. Cancer Discov. 2020 Jan;10(1):104-123. doi: 10.1158/2159-8290.CD-19-1006. Epub 2019 Oct 24. Cancer Discov. 2020. PMID: 31649109 Free PMC article.
Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity.
Yang MH, Tran TH, Hunt B, Agnor R, Johnson CW, Shui B, Waybright TJ, Nowak JA, Stephen AG, Simanshu DK, Haigis KM. Yang MH, et al. Among authors: simanshu dk. Cancer Res. 2023 Oct 2;83(19):3176-3183. doi: 10.1158/0008-5472.CAN-22-3210. Cancer Res. 2023. PMID: 37556505 Free PMC article.
RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome-associated cardiac hypertrophy.
Cuevas-Navarro A, Wagner M, Van R, Swain M, Mo S, Columbus J, Allison MR, Cheng A, Messing S, Turbyville TJ, Simanshu DK, Sale MJ, McCormick F, Stephen AG, Castel P. Cuevas-Navarro A, et al. Among authors: simanshu dk. Sci Adv. 2023 Jul 14;9(28):eadf4766. doi: 10.1126/sciadv.adf4766. Epub 2023 Jul 14. Sci Adv. 2023. PMID: 37450595 Free PMC article.
Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
Bonsor DA, Alexander P, Snead K, Hartig N, Drew M, Messing S, Finci LI, Nissley DV, McCormick F, Esposito D, Rodriguez-Viciana P, Stephen AG, Simanshu DK. Bonsor DA, et al. Among authors: simanshu dk. Nat Struct Mol Biol. 2022 Oct;29(10):966-977. doi: 10.1038/s41594-022-00841-4. Epub 2022 Sep 29. Nat Struct Mol Biol. 2022. PMID: 36175670 Free PMC article.
RIT1 oncoproteins escape LZTR1-mediated proteolysis.
Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F. Castel P, et al. Among authors: simanshu dk. Science. 2019 Mar 15;363(6432):1226-1230. doi: 10.1126/science.aav1444. Science. 2019. PMID: 30872527 Free PMC article.
60 results